The Preparation of Salicylic Acid From Phenol

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Phenyl salicylate, Salol , another derivative of the acid is a very important pharmaceutical; but because of its cost, other salicylates are sub- 21.
stituted. V/hen phosphorous oxychloride is allowed to react with the acid phenyl sali- cylate is thus formed. Acetyl salicylic acid, "Aspirin", is prepared from salicylic acid and acetyl chloride. "Aspirin finds extensive use in the treatment of rheumatic conditions. All of the Salicylic preparations taken internally, are used for T;he henefit of
...the salicylic acid v/hich is liberated in the decomposition of the compound. Quinine salicylate is one of the few compounds, prepared directly from the sodium salt.
Among the most important salicylic salts vi'hich are used in the preparation of anti- rheumatic compounds are: tolypyrinesalicylate , salicylic-sulfonic acid, salicylamide, salicyl-a- methyl -phenyl -hydrazone and methl-acetyl-salicylate.
It is interesting to note that in the production of the raethyl-acetyl-salicylate, anhydous zinc chloride is said to act as a catalytic agent.


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