The Purin Bodies of Food Stuffs And the Rôle of Uric Acid in Health And Disease
The Purin Bodies of Food Stuffs And the Rôle of Uric Acid in Health And Disease
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3800 „ TOO „ „ =011 2500 „ 0-50 „ „ =007 But as early as 1867 Gorup recognised the import- ance of the nuclein bodies in regard to metabolism, and Kossel, in 1881, obtained xanthin bodies from pure nuclein by hydrolytic cleavage. His declara- tion in 1882, that nuclein might be a source of uric acid with hypoxanthin as an intermediary body led to a series of experiments in which rabbits, cats and dogs were fed with nuclein bodies, and increased amounts of urinary purins demonstrated. The work o...f Horbaczewski, who showed that oxidation of fresh splenic pulp by bacterial agencies, produced uric acid of the same nitrogenous value as that of the nucleins of the tissues, and that nuclein prepared from splenic substance, dissolved in weak alkali and digested with blood at 40° C, yielded uric acid, led up to the theory that the decomposition of nuclein in the tissues yielded xanthin and hypoxanthins, and that these bodies, after oxidation, were excreted as uric acid. The increased amount of uric acid, eliminated after meals rich in nucleins and present in the urines of leucocythsemic patients, supported Horbaczewski's further contention that disintegra- tion of leucocytes was the source of uric acid.
What to read after The Purin Bodies of Food Stuffs And the Rôle of Uric Acid in Health And Disease?
You can find similar books in the "Read Also" column, or choose other free books by Isaac Walker Hall to read onlineMoreLess
To quickly assess the difficulty of the text, read a short excerpt:
3800 „ TOO „ „ =011 2500 „ 0-50 „ „ =007 But as early as 1867 Gorup recognised the import- ance of the nuclein bodies in regard to metabolism, and Kossel, in 1881, obtained xanthin bodies from pure nuclein by hydrolytic cleavage. His declara- tion in 1882, that nuclein might be a source of uric acid with hypoxanthin as an intermediary body led to a series of experiments in which rabbits, cats and dogs were fed with nuclein bodies, and increased amounts of urinary purins demonstrated. The work o...f Horbaczewski, who showed that oxidation of fresh splenic pulp by bacterial agencies, produced uric acid of the same nitrogenous value as that of the nucleins of the tissues, and that nuclein prepared from splenic substance, dissolved in weak alkali and digested with blood at 40° C, yielded uric acid, led up to the theory that the decomposition of nuclein in the tissues yielded xanthin and hypoxanthins, and that these bodies, after oxidation, were excreted as uric acid. The increased amount of uric acid, eliminated after meals rich in nucleins and present in the urines of leucocythsemic patients, supported Horbaczewski's further contention that disintegra- tion of leucocytes was the source of uric acid.
What to read after The Purin Bodies of Food Stuffs And the Rôle of Uric Acid in Health And Disease?
You can find similar books in the "Read Also" column, or choose other free books by Isaac Walker Hall to read onlineMoreLess
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