The Theory of Ions a Consideration of Its Place in Biology And Therapeutics

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A pure ion effect parallels the ionic concentration, and not the concentration of the salt in the solution. Cations and anions in many instances antagonise one another ; and the effect of a salt upon various substances, e. G. Protein, is the sum of the effects of different ions. We are far from a satisfactory insight into the nature of the effect of ions, which may be chiefly electrical in character and brought about by the polarity of matter. Nevertheless examples of such ion effects are to be... found in pharmacology of the iodides, cocaine and other drugs, in the absorption of water by muscle, in the sense of taste, changes in the state of the proteins, etc. In the living organism we have to deal with complex mixtures of crystalloids and colloids, between which there exist relations so intimate and varied that some of them are still incapable of elucidation. " Connected with the uninterrupted vital activity of the cell, the anabolism and catabolism of its substance, is the conversion of crystalloids into colloids, and colloids into crystalloids ; and this at present unexplained transformation serves at one time to protect a sub- stance from oxidation, as in the conversion of crystalloidal sugar into colloidal glycogen ; at another time it protects the protoplasm against the poisons of its own products.

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