Transactions of the ... Annual Session of the Medical Society of the State of North Carolina [serial] 37 (1890)
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A number of cases have been reported in which chloralamide was administered by enema with satisfactory results, no irritation being produced, even after frequent repetition, though its action was slower than when given by the mouth. It is best to give it about two hours after eating, and as its action is somewhat tardy, it should be given from one-half to two hours before the desired sleep is expected to begin. The usual dose is 15 to 60 grains, though rarely should the dose exceed 30 to 45 gra...ins, at very serious and annoying after effects have followed the administration of large doses, as was the case of two healthy young women who received a dose of GO grains each in the afternoon; each in an hour complained of dizzi- ness and great excitement, while one complained of giddiness and staggering, with severe headache in the posterior part of the head, nausea and an inclination to vomit. In one of these cases the stomach was washed out and found to be empty, though this procedure did not succeed in arresting nausea, showing that chloral- amide is absorbed and that the effect must be due to the presence of the substance in the blood, by which the nervous system is effected.
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