Truth And Poetry Concerning Uric Acid: An Epitome of the Present State of Knowledge of the ...

Cover Truth And Poetry Concerning Uric Acid: An Epitome of the Present State of Knowledge of the ...
Truth And Poetry Concerning Uric Acid: An Epitome of the Present State of Knowledge of the ...
Barker, Lewellys F. (Lewellys Franklin), 1867-1943
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Minkowski, O. : Ueber den EInfluss der Leberextlrpatlon auf den Stoffwechsel, Arch. f. exper. Path. u. Pharmakol., Leipz., vol. xxl, 1886, pp. 41-87.
receivod some support thi-oiigh the facts that the feeding of lactic flcid to birds incroaBep uric-aoirl uxcrotioB (Wicnci'j ]0(JS^). and that whnrj lactic acid is pas^seil through tJiG isolated birdV liver uric acid is foriued from it {Kowalewski and Salaekiu, 1001).
Ill view of tJiG high degree of probability that lactic acid takes part In the e
...yn thesis of uric acid io hirds, it became important that the proeeHS should be more cloBcly ex»i mined with speeial refer- ence to its pxnct nature. Wicner^''^ in 1909, demon- strated that the administration of glycerin, of vari- ons oxyacid^j and especially of dibasic acida (of the aliphatic series) contninlng three carbon atoms, along with urea, increa^eB markedly the formation of uric acid. Lalioratory experiments had shown that nrea can nnitc with dilxafiic acids containin}^ three carbon atoms to form componnds called nreids, and that certain nf thc^e nreids can eom- bine with another molecule of urea to form uric acid* While the feeding of any dibasic acid con- taining three carbon atoms to birds increases the nric-ticid formation, Wiener found that, when lie used isolated organs^, only one dibasic acid, namely, tartronie acid (or its iireid) was effectuaL He concluded, therefore, that other dibasic acids or their ureids ore transformed into the nreid of tar- tronie acid in the prooess of uric-acid synthesis.

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