Truth And Poetry Concerning Uric Acid: An Epitome of the Present State of Knowledge of the ...
Truth And Poetry Concerning Uric Acid: An Epitome of the Present State of Knowledge of the ...
Barker, Lewellys F. (Lewellys Franklin), 1867-1943
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Minkowski, O. : Ueber den EInfluss der Leberextlrpatlon auf den Stoffwechsel, Arch. f. exper. Path. u. Pharmakol., Leipz., vol. xxl, 1886, pp. 41-87. receivod some support thi-oiigh the facts that the feeding of lactic flcid to birds incroaBep uric-aoirl uxcrotioB (Wicnci'j ]0(JS^). and that whnrj lactic acid is pas^seil through tJiG isolated birdV liver uric acid is foriued from it {Kowalewski and Salaekiu, 1001). Ill view of tJiG high degree of probability that lactic acid takes part In the e...yn thesis of uric acid io hirds, it became important that the proeeHS should be more cloBcly ex»i mined with speeial refer- ence to its pxnct nature. Wicner^''^ in 1909, demon- strated that the administration of glycerin, of vari- ons oxyacid^j and especially of dibasic acida (of the aliphatic series) contninlng three carbon atoms, along with urea, increa^eB markedly the formation of uric acid. Lalioratory experiments had shown that nrea can nnitc with dilxafiic acids containin}^ three carbon atoms to form componnds called nreids, and that certain nf thc^e nreids can eom- bine with another molecule of urea to form uric acid* While the feeding of any dibasic acid con- taining three carbon atoms to birds increases the nric-ticid formation, Wiener found that, when lie used isolated organs^, only one dibasic acid, namely, tartronie acid (or its iireid) was effectuaL He concluded, therefore, that other dibasic acids or their ureids ore transformed into the nreid of tar- tronie acid in the prooess of uric-acid synthesis.
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