Urinary And Renal Derangements And Calculous Disorders : Hints On Diagnosis And Treatment

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The gradual wasting, contraction, and condensation of the structural elements of the kidney is by far the most common form of disease which seriously deranges the action of the organ, and which results at length in its irreparable damage and destruc- tion as a secreting organ. These changes are associated with, and sometimes are the cause of, changes in the structure of the walls of the small arteries and capillaries affecting the nutrition and action, it may be, of all the tissues of the body.
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This chronic wasting of the renal structure seems to be, at least in many instances, a consequence of the state of system which induces gout, and is often associated with other effects of long . continued alcohol taking and irregular living, both as regards the quantity and nature of the food and the time of taking it. A form of the affection accompanies degenerations of various tissues which result from chronic poisoning by lead. But occasionally the disease is met with at so early an age that it cannot be ac- counted for by any of these circumstances, and must be attributed to developmental defects, or to pathological changes occurring during intra-uterine life.


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